Secondary hyperoxaluria is a disease with significant unmet medical need. Patients demonstrate wide ranging severity, from manageable symptoms to severe and chronic complications.

There are two types of Secondary (2°) Hyperoxaluria : Idiopathic Hyperoxaluria (IH) and Enteric Hyperoxaluria (EH) ^{1, 2, 3} .

IH is the most common type, and mostly observed in individuals with calcium oxalate kidney stones^{1, 4, 5}. EH is partly caused by an underlying gastrointestinal complication associated with a malabsorption of oxalate. In these patients, oxalate becomes more available for absorption ² , which can cause severe kidney damage and can lead to end-stage renal failure.

Oxidien estimates that there are 200,000 – 250,000 patients with enteric hyperoxaluria in the U.S. alone and  4 – 5 million people that are hyperoxaluric stone formers in the general U.S. population. For more information on the unmet need and the market in the U.S. and worldwide.